Background: To check for better and faster effectiveness of nasal sedation achieved by dexmedetomidine and midazolam on fearful children needing dental treatment.

Aim: The aim of the study was to compare the nasal sedative effects of dexmedetomidine and midazolam on fearful children needing dental treatment.

Methodology: This In vitro study was conducted in Seema dental college and hospital, Rishikesh. Patients aged 2-10yrs were included with at least two similar teeth needing pulp therapy. Standard vital signs would be measured pre and post administration of sedative. Frankel’s rating and Sedation Scale will be used to analyse the fearfulness and level of sedation respectively. Cases would be referrals/outpatient in college for arrangement to receive dental treatments under sedation. The combination of drugs will be administered at the start of each dental session by dental operator under the guidance of anaesthesiologist and patient will be blinded to the drugs combination during the visit.