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VOL. 6, ISSUE 1 (2024)
Assessment of the effectiveness of mangosteen peel methanol extract as an analgesic and antipyretic in male wistar rats
Authors
Kang Xiaojun, Liena
Abstract
Plants that have the potential as
analgesic-antipyretic compounds are mangosteen fruit (Garcinia mangostana L).
Methanol extract from the peel of mangosteen fruit (Garcinia mangostana L.)
contains several compounds, including saponins, alkaloids, flavonoids,
triterpenoids, tannins, and polyphenols. The presence of flavonoids in
mangosteen peel can inhibit prostaglandins, thus providing antipyretic effects.
This study aims to evaluate the effectiveness of analgesic and antipyretic
effects of methanol extract from mangosteen peel on Wistar rats. This research
was conducted in January 2024 and utilized an experimental post-test-only
Control Group Design. Data were analyzed using IBM SPSS 25, with normality
tested using Shapiro-Wilk. The results indicate that mangosteen peel methanol
extract contains various phytochemicals, including Alkaloids, Saponins,
Flavonoids, Tannins, Steroids, and Terpenoids. The methanol extract
demonstrates potential antipyretic and analgesic effects on male Wistar rats,
especially at the highest dose (150 mg/kg body weight). The antipyretic effect
was observed after 5 hours of administration, while the analgesic influence was
evident simultaneously. Although the control group showed a significant
decrease in body temperature 1 hour after treatment, the mangosteen peel
methanol extract group III exhibited a more pronounced decrease at various
times post-treatment than the control and standard groups. Hematological
analysis revealed a reduction with an increase in the dose of mangosteen peel
methanol extract. This potential makes the excerpt interesting for further
research in drug development.
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Pages:56-60
How to cite this article:
Kang Xiaojun, Liena "Assessment of the effectiveness of mangosteen peel methanol extract as an analgesic and antipyretic in male wistar rats". International Journal of Educational Research and Development, Vol 6, Issue 1, 2024, Pages 56-60
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