It is generally accepted that one of the main difficulties of employees on maritime industry is the effective approach of medical care at sea in harsh weather conditions and long distances from ashore by absence of on-board doctor and limited equipment or medicines. The objective of the present study was to examine the health issues of seafarers and to approach an e-learning platform that could promote good health aboard. Data were collected from merchant ship personnel in the Piraeus Port, Athens, Greece (n = 61) via web-questionnaires and interviews. A descriptive data analysis was performed. The research results revealed that participants were interested in an e-learning education system by animation or digital texts for first aid and management of work-related emergencies and chronic or acute diseases as well as basic skills on medical care aboard. Seafarers reported that this system could achieve to improve their communication with a health specialist by telemedical assistance services, to keep medical knowledge up to date, and to promote their self-confidence in handling real emergencies effectively, leading to the prevention of unnecessary evacuations or deviations.