This study focused on Students’ Adoption of E-Learning Platforms in Uganda and Nigeria. The aim of the study was to explore factors affecting students’ Adoption of E-Learning Platforms. A questionnaire was developed based on Theory of Planned Behavior (TPB) and Technology-Organization-Environment (T-O-E). Data was collected from 204 university students in Uganda and Nigeria. Kaduna State University students portray a higher degree of e-Learning adoption compared to the Makerere university students. Perceived behavioral control, change agents were very significantly correlated with actual use of e-learning At the Nigerian University. At the Ugandan university, technology development, behavioral intention to use system have significant positive association with Actual use of e-learning. Multiple regression results showed that both planned behavior theory and technology-organization-environment theory constructs are significant predictors of e-Learning adoption in the two universities at 32.5% and 14.4% respectively. Therefore, universities should create an enabling technology environment so as to boost student e-learning adoption.