Now days the potential toxic effect of heavy metals in the aquatic environment and in organisms has been intensively studied. Grey mullet (Mugil cephalus) is commercially important fast moving marine fish species especially during warm weather. The M. cephalus is an omnivore and usually inshore, entering estuaries and lagoons. The aim of the present study was to determine the heavy metal contents Arsenic (As), Lead (Pb), Cadmium (Cd), Mercury (Hg), Iron (Fe),Copper (Cu), and Zinc (Zn), in water and tissues like gills, liver and muscle of the grey mullet (Mugil cephalus). The fish samples were collected from two different locations like Krishnapatnam and Nelaturu from the Nellore coast. The sample preparation was performed by acid microwave digestion and heavy metals analysis was carried out by AAS. Detected levels of heavy metals in the studied regions represented in Table.1 Heavy metals in coastal water samples, and Table.2 Heavy metals in fish tissues. The results for other heavy metals presented lower to higher amounts at Krishnapatnam and Nelaturu coastal water and fish (M.cephalus) tissues samples.